“Intracellular Communication in the Eye lens” The major objective of this grant is to determine the specific mechanistic role of Cx43 hemichannels in mediating the anabolic effect of mechanical loading on the skeletal tissues. “Connexin channels in transducing mechanical signals in bone” The major objective of this study is to elucidate the underlying mechanism of proteoglycans in toughening of bone and its contribution to the age-related bone fragility. “Proteoglycans and age-related deterioration of bone toughness” RO1 (AR076190) Jiang (MPI) and Wang (Contact PI). To investigate the functional significance of gap junctions, hemichannels and integrins in signaling transmission, skeletal tissue remodeling and cancer metastasis of breast cancer and osteosarcoma. To determine the gap junction or hemichannel-dependent and independent mechanisms of connexins in cell growth, differentiation and lens development.Ģ). Hemichannels mediate the passage of biological molecules, especially for cells under stress conditions. Therefore, gap junctions provide the critical means for cell survival and for physiological regulation of cellular functions. In addition to forming gap junctions, connexins are recently shown to form hemichannels, un-apposed halves of gap junction channels. For cells like bone osteocytes, signals generated by mechanical loading can be transmitted extensively through gap junction channels. Thus, lens survival and homeostasis are uniquely dependent upon intercellular communication via gap junctions with the cells localized at the lens surface. Cells like lens fibers within the interior of the vertebrate eye lens neither have blood supply nor organelles. Gap junction channels permit small metabolites, ions, and second messengers to pass from cell to cell. These channels are formed by a family of proteins called connexins. Gap junctions are clusters of transmembrane channels that connect the cytoplasm of adjacent cells. Cells connect and communicate via an information superhighway named gap junctions.
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Nicieza gave Deadpool the real name of "Wade Wilson" as an inside-joke to being "related" to "Slade Wilson", Deathstroke. Upon seeing the costume and noting his characteristics (killer with super agility), Nicieza contacted Liefeld, saying "this is Deathstroke from Teen Titans". Liefeld, also a fan of the Teen Titans comics, showed his new character to then-writer Fabian Nicieza. Because of this, he decided to give weapons to his new characters as well. Liefeld's favorite comic title before X-Men was Avengers, which featured weapons like Captain America's shield, Thor's hammer and Hawkeye's bow and arrow. According to Nicieza, Liefeld came up with the character's visual design and name, and Nicieza himself came up with the character's speech mannerisms. įurther information: List of Deadpool titles 1990sĬreated by artist/writer Rob Liefeld and writer Fabian Nicieza, Deadpool made his first appearance in the pages of The New Mutants #98 cover dated Feb. He will continue playing the character in Deadpool 3 (2024), set in the Marvel Cinematic Universe. Reynolds attributes Cable & Deadpool #2 to what got him invested in the character and inspired him to bring the character to the movies. Reynolds himself would eventually portray the character in the X-Men film series, appearing in X-Men Origins: Wolverine (2009), Deadpool (2016), and its sequel Deadpool 2 (2018). In the 2004 series Cable & Deadpool, he refers to his own scarred appearance as " Ryan Renolds crossed with a Shar-Pei". The character's popularity has seen him featured in numerous forms of other media. He is known for his tendency to joke incessantly and break the fourth wall for humorous effect. Deadpool is the alter ego of Wade Wilson, a disfigured Canadian mercenary with superhuman regenerative healing abilities. In his comic book appearances, Deadpool is initially depicted as a supervillain of the New Mutants and X-Force, though later stories would portray him as an antihero. Created by Fabian Nicieza and Rob Liefeld, the character first appeared in New Mutants #98 (December 1990). Joe Kelly (−1, 0, 1–33, Annual #1997–1998), Christopher Priest (34–45)ĭeadpool is a character appearing in American comic books published by Marvel Comics. With the Cruzer Blade, SanDisk has joined the ranks of companies offering ultra-small USB flash drives. While the Cruzer Blade had no problems holding its own when reading, it took more than four minutes to write our test data. This benchmark gives each drive an overall score, or "Drive Index," based on the results of its read and write tests. One of Sandra's more useful tests is the File System benchmark. While I am not a big fan of SiSoftware Sandra's optical drive benchmarks, it is a great tool if you want to test a system's performance quickly and easily. When tested with ATTO, the Ultra Backup topped out at 19.9 MB/s when reading and 5.5 MB/s when writing. The test was run using blocks ranging in size from 0.5KB to 8192KB and the total length set to 256MB. I also used ATTO Disk Benchmark to test the Cruzer Blade's sequential read and write speeds. Looking at the screenshot above, you can see that the Cruzer Blade had average read and write speeds of 19.1 MB/s and 5.7 MB/s, respectively, as well as a burst speed of 20.2 MB/s. The performance here was very similar to what we saw with CrystalDiskMark. Next, I used HD Tach to test the Cruzer Blade's read, write and burst speeds as well as its seek times and CPU usage. Using CrystalDiskMark we can see that the drive is able to read at nearly 20 MB/s and write at 5.7 MB/s. SanDisk doesn't really say what kind of speeds the Cruzer Blade is capable of. This benchmark tool measures the performance of a storage device by testing its sequential read and write speeds as well as its random read and write speeds using blocks 512K and 4K in size. To get a feel for the "real world" performance, I also copied and pasted 500MB of random files and directories in Windows Explorer.įirst, I ran a few quick tests using CrystalDiskMark. To test the performance of the SanDisk Cruzer Blade, I ran a series of benchmarks using CrystalDiskMark 3.0, HD Tach RW 3.0.4.0, ATTO Disk Benchmark 2.46 and SiSoftware Sandra Lite 2010.SP2. For the operating system, I installed a fresh copy of Windows 7 Enterprise. The computer came equipped with an Intel Core 2 Duo E8400 3.0GHz CPU, 2GB of DDR2 800MHz memory, Seagate Barracuda 7200.10 ST3250310AS 250GB SATA hard drive, NVIDIA Quadro FX570 256MB PCIe graphics card and Intel 82567LM-3 gigabit network card. The test system used in this review was an HP dc7900. 410 bore models on a new scaled-down receiver size, and in 1972, a 20-gauge Lightweight ("LW") version was introduced on the same sized receiver, and all of the smaller gauges today are produced on that size receiver. In 1969, Remington introduced 28 gauge and. All Remington 870 versions are built on the same platform and receiver, but there are small differences that can be more than just cosmetic. There are hundreds of variations of the Remington 870 in 12, 16, 20, 28 gauges and. Remington 870 fitted with a pistol grip, Surefire light, and M4-type stock Remington Model 870 Wingmaster with 20" Home Defence barrel. Variants Remington 870 Police Magnum 14 inch barrel (customize painted with cerakote color "Gunmetal") Remington 870 Express Tactical fitted with aftermarket Remington ShurShot stock. The cut-out, combined with modified machining on the underside of the slide assembly, allows the action to be opened with a shell on the carrier. Guns with this modification can be identified by the "U"-shaped cut-out on the carrier, visible from below the gun. The potential issue was resolved with the introduction of the "Flexi Tab" carrier. This was caused by the shell slipping out of the magazine under the bolt in the receiver to bind the action, requiring rough treatment of the action or even disassembly. The 870's production for over 30 years had a design flaw whereby a user could fail to press a shell all the way into the magazine when loading - so that the shell latch did not engage the shell - which could result in tying up the gun. The following year the availability was expanded to the 20 gauge and included other barrel lengths. Initially, the Rem Chokes were offered only in 12 gauge in barrel lengths of 21", 26", and 28". In 1986 Remington introduced the new Remington "Rem Choke" system of screw-in chokes (also fitted to Remington model 1100 auto-loading shotguns at the same time). The original 870 models were offered with fixed chokes. Several parts of the 870, such as buttstocks and magazine tubes, will interchange with the semi-automatic Remington 1100 and 11–87. Twelve gauge stocks will also interchange on the older 12-gauge-sized 20-gauge receivers, although modification is needed to fit the smaller sized 20-gauge receivers employed since the late 1970s. The basic fire control group design was first used in the automatic 11–48. The action, receiver, fire control group, safety catch and slide release catch of the Remington Model 870 shotgun are similar to those used on the Remington Model 7600 series pump-action centerfire rifles and carbines. It has dual action bars, internal hammer, and a bolt which locks into an extension in the barrel. The gun comes with a plug for migratory bird hunting which reduces the magazine's capacity to two rounds. The 870 features a bottom-loading, side ejecting receiver and a tubular magazine under the barrel. On April 13, 2009, the ten millionth Model 870 was produced. By 1996, spurred by sales of the basic "Express" models, which were added as a lower-cost alternative to the original Wingmaster line, sales topped seven million guns. As of 1983, the 870 held the record for the best-selling shotgun in history, with three million sold. Remington sold two million guns by 1973 (ten times the number of Model 31 shotguns it replaced). To achieve better sales, Remington produced the Model 870 in 1950, which was more modern and reliable in its construction, easy to take apart and maintain, and relatively inexpensive. Consequently, it struggled in sales compared to the Winchester Model 12. The Model 31 was marketed as the “ball-bearing repeater” and was well-received, but its many machined and handfitted parts made the gun expensive to manufacture. John Browning designed the Remington Model 17 (which was later adapted by Ithaca into the Ithaca 37), which served as the basis for the Remington 31. John Pedersen designed the fragile Remington Model 10 (and later the improved Remington Model 29). The Remington 870 was the fourth major design in a series of Remington pump shotguns. It is widely used by the public for shooting sports, hunting and self-defense, as well as by law enforcement and military organizations worldwide. The Remington Model 870 is a pump-action shotgun manufactured by Remington Arms Company, LLC. Also cantilever and receiver-mounts for scopes 410 boreģ+1, 4+1, 5+1, 6+1, or 7+1 round internal tube magazine, or an external 6+1 box magazineīead, twin bead, adjustable open sights, or ghost ring (all iron sights). Pinckneyġ2 gauge, 16 gauge, 20 gauge, 28 gauge, or. L.Ray Crittendon, Phillip Haskell, Ellis Hailston, G.E. Note that charging your devices will drain the battery, so you should recharge the device fully after each time you use it for this purpose. Once that happens, you should be able to charge your device without a problem. If it requires more than 15A, the 950 will temporarily power off, but if you unplug it and plug it back in again, the circuit breaker will reset. To charge your accessories, open the front panel of the 950, and plug your device into the DC power outlet. The 950 is equipped with a circuit breaker that will reset automatically if it becomes overheated. You can also use your 950 to charge any 12V DC accessory. You can also charge the battery while you’re driving if you plug the accessory cable into the battery and the other end into the car’s lighter socket. *Don’t operate the battery while it’s charging* You should charge the battery every month to ensure it will last as long as possible. You should not leave it stored uncharged for too long, as this will deplete the battery’s life span. Warm environments will speed up the loss of power in the battery. You should store your battery somewhere between 40 and 70 degrees Fahrenheit. Charging can take up to 48 hours, but once fully charged, the battery will switch to ‘float-mode’ so it will not overcharge and become damaged. You will need a 120V AC source from which to charge your battery. The charge level will be most accurate when the battery has been disconnected from all devices and power sources for at least an hour, and up to a day. Press the button labeled ‘Display, to check the battery’s charge. This will ensure that you are never in a situation where you need a jump but your own battery needs a jump too! The battery in the Diehard is sealed and non-spillable, but it can still be a fire hazard and cause injury if not properly used, so use it in a well-ventilated area and keep it out of the reach of children.įirst, you’ll need to charge the battery immediately after you buy it, after every use, and every 30 days as well. I have a direct zenith and Ecobank log nowĭon't give me small children zenith Bank or Ecobank account. don't give me new accountIf you have zenith Bank account or Ecobank account that can take up to 50,000,000 naira you drop for Instant loading. Please and please the account needed is account that has a good transaction history account that have run transaction of millions for the past monthĭon't give me small children zenith Bank or Ecobank account. 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Oh its a vibe yeah yeah Dim the lights Oh its a vibe yeah Get high Its a vibe oh its a vibe yeah Verse 2. I don't have all the games on hand right now, so I went and tested those inside my "problematic games" folder, which are the ones I use mostly for compatibility improvements and testing. The sound is very different in many areas, kinda high pitched. * libwupc and libwiidrc are also GPL, which can be found here:Ĭlick to expand.Finally tried it. * WiiSXR is GNU GPL and the source can be found here: * WiiSX is GNU GPL and the source can be found here: * Please see the following link for details: The starting point for this code base will be Mystro256's WiiSXR, a continuation ofĭaxtsu's libwupc mod of wiisx, which is in turn based off of Matguitarist's "USB mod5". # The following is the basic code informationįork of WiiSXR (a port of PCSX-R), a PSX emulator for the Gamecube / Wii / Wii U. ※※※ It reads a font file in a fixed location, So make sure that exists ※※※ I don't know anything about OpenGL, and I don't know if I can use grrlib. * Use the display mode of GL to provide image quality and performance. * Improve GTE code to provide 3D game speed.Īlthough I used paired single instruction, but the speed is basically not improved # Goals(Please help me, or let us work together.) * Other minor corrections, such as disc changing and automatic fixed of some games. * For some customed Chinese culture games, specific BIOS is automatically loaded.įor example: sd:\wiisxrx\isos\武藏传.ISO => sd:\wiisxrx\bios\武藏传.bin So it can only be made into a specific font.įont char information: first two byte: BigEndianUnicode char code, followed by a character picture in IA8 format with a size of 24 * 24. However, it encountered a memory leak problem, resulting in automatic exit. (Part of the division instruction uses a static compilation instruction)Īt first, I wanted to refer to snes9xgx and support TTF font library. * Modification of some dynamic compilation instructions, such as sllv, SRLV, srav, FF9 and biohazard3 can be run. The sound quality of the system has been more improved. * Combined the dfsound module of pcsxrearmed and used the SDL Library. Many games that could not be run or had problems before can be run. * Incorporating the CDROM and cdiso codes of pcsxrearmed, the compatibility of the system has been more improved. # The following changes have been made to the code based on wiisxrx. Please refer to the following address for details: I have also invested a lot of time and energy in this project recently, and released the first version. Old message-įirst, thanks to the efforts of the original authors of wiisxrx, wiisxr, wiisx, I can play PS games on Wii. When selecting files, cue files are displayed first, and other files with the same name are not displayed The system automatically reads the font from SD and USB, If there is no font, use the embedded English fontĤ. Fix the error When open the "Settings" section and then click on the "Saves" buttonģ. In order to support more languages, modify the language selection methodĢ. The compatibility of the game has been further improved, and some more games can be run. Please help test the multi track games.ģ: Except the cdda part, the CDROM code of pcsxReArm has almost been merged. 3 update-ġ: The problem that the sound pitch is too fast has also been solved, and many game sounds have become correct.Ģ: Basically, it supports CDDA. Some other casual fans may know Minnie Riperton best not by a song, but by her daughter, Maya Rudolph. He produced the whole album – “Perfect Angel” – but he used a pseudonym: “El Toro Negro.” It was to avoid a contract dispute with his label, Motown Records. To get the magic of that note near the song's conclusion … it makes listening to the song feel like the slow unwrapping of a gift – undoing the ribbons and tearing off the paper before opening the box. A note arriving late in a song that felt like it had already done its work. At the three-minute mark of that tune, a perfect piercing note unfolds over the birdsong and the dreamlike electric piano. The casual music fan may know Minnie Riperton best not by a song, but by a song within a song. An album that might, if they were lucky, hit the charts with a ferocity that no Minnie album had before. And like that, there would be an album that sounded new. Call up some of Minnie’s old friends and collaborators. They knew they could put the vocals over new arrangements. They would latch on to the waves of grief and sentimentality that had taken over after Minne’s passing. They weren’t very cohesive, and under many other circumstances, they would have been disposed of. She had left behind scraps of recordings from past sessions. They were armed with a disparate arrangement of prerecorded vocals, and a host of willing guest stars, She had died one year earlier, after a years-long battle with breast cancer. In the spring of 1980, producers set out to bring Minnie Riperton back to life. Support KCRW original programs like Lost Notes by donating or becoming a member. You can find all the episodes from Lost Notes: 1980 here. This season, the poet and cultural critic Hanif Abdurraqib explores a single year: 1980 - the brilliant, awkward and sometimes heartbreaking opening to a monumental decade in popular music. This piece was written for the KCRW music documentary podcast Lost Notes. It is possible to view Chrome videos with MX Player, but you must take the following actions: How can I use MX Player to play videos from Chrome? MX Player will be accessible on your Firestick after installation. Install the MX Player app by downloading it and following the setup instructions.Go to the MX Player download page now using the Downloader app.Activate the checkbox to permit downloads from unidentified sources in the app’s settings.On your Firestick, launch the Downloader app.After you have the Downloader software, take the following actions: The Downloader app must first be downloaded to your Fire TV in order to proceed with installing MX Player on your Firestick. How do I install MX Player on a Firestick? This ensures a secure and uninterrupted watching experience for your child as they are able to watch the film without using any other functions on your device.
"/api/messages", methods=) def messages(): # Main bot message handler. ModuleDict can be indexed like a regular Python dictionary, but modules it contains are properly registered, and will be visible by all Module methods. They are used to store data in a key-value pair format. Use square brackets or get() method to access a value by its. # Listen for incoming requests on /api/messages. Dictionary in Python is one of the most popular data structures. A Python dictionary is a collection of key-value pairs, where each key has an associated value. This is not required for production, since # the AppId will have a value.ĪPP_ID = SETTINGS.app_id if SETTINGS.app_id else uuid.uuid4()īOT = ProactiveBot(CONVERSATION_REFERENCES) If you are not yet on Python 3.5 or need to write backward-compatible code, and you want this in a single expression, the most performant while the correct approach is to put it in a function: def mergetwodicts (x, y): '''Given two dictionaries, merge them into a new dict as a shallow copy.''' z x.copy () z.update (y) return z. # We generate a random AppId for this case only. A dictionary is a collection which is ordered, changeable and do not allow duplicates. To initialize a dictionary in Python, the setdefault() method can be used by specifying the key-value pairs within the comprehension. This expectation is not checked at runtime but is only enforced by type. TypedDict declares a dictionary type that expects all of its instances to have a certain set of keys, where each key is associated with a value of a consistent type. CONVERSATION_REFERENCES: Dict = dict() # If the channel is the Emulator, and authentication is not in use, the AppId will be null. Dictionaries are used to store data values in key:value pairs. TypedDict (dict) Special construct to add type hints to a dictionary. The Bot will add conversation references when users # join the conversation and send messages. # Send a trace activity, which will be displayed in Bot Framework Emulator await nd_activity(trace_activity) |
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